round button
Categories
How To Order | Shipping Policy | FAQ | Contact Us

Customer Support: +18102015692
Refer Friend

Vardenafil Tablets
♂ Brand Levitra Bottle

  • Cialis Tablets
  • BRD005
  • In Stock

Premium High Quality Product & Original Active Substance!

Select Doses:

   Manufacturer's Suggested Retail Price (MSRP) per pill is $8.68 ! Buying from us will save you at least 45.97%

Package per pill Price SAVINGS BONUS Order
20mg * 30 pills
$4.69 $140.70 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 60 pills
$3.56 $213.60 $67.80
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 90 pills
$2.99 $269.10 $153.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 120 pills
$2.64 $316.80 $246.00
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free standard airmail service

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum.

Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs)

Levitra is used for the treatment of men’s erection problems. It works faster than Sildenafil (Viagra®) and it has lower chance to cause visual disturbance side effect. This medicine is for oral administration, it is recommended to take the pill 1 hour before you are going to have intimacy with your partner. For most men, the recommended starting dose of Levitra is 10mg per day. The minimum effective dose – 5 mg and the maximum dose that you can take is 20 mg. You can take Levitra on an empty stomach or with food as the mealtime doesn’t influence on the work of the drug

Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum.

This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum.

This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.

This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. M1 shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil.

Absorption: Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

Route of elimination: After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).

Half life: 4-5 hours

All medicines may cause side effects, but many people have no, or minor, side effects. Some medical conditions may interact with Vardenafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common side effects may include: flushing (warmth, redness, or tingly feeling)stuffy nose, sinus pain headache, dizziness upset stomach or back pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Edith
13/Jan/2024

An excellent drug. Brought back performance of 20 year old. At lower doses the effect can vary. Suggest the 50mg about 2 hours before sex, but will work well for long duration after that. Drink 1-2 glasses of water when taking to improve absorption. Exercise, relax and enjoy.

Melissa
07/Jan/2024

I'm 54 years old with high blood pressure and ED. Have tried everything on the market for the past 2-3 years, unsuccessfully. Got the 50mg Cialis. Within 30 minutes was like a teenager with my wife. Unbelievable sex. Unbelievable pill.

Lynn
13/Mar/2023

A very effective drug. State of mind important. Stress diminishes effect.

Martha
12/Mar/2023

I have been on Cialis 50mg daily for 2 years. Night time bathroom trips average once. Improved energy levels and constant state of semi-arousal. I've had no side effects from the 50mg regimen. I will be 60 years old in 3 months!

Write a review

Note: HTML is not translated!
    Bad 
 
 
 
 
 Good
TOP
a